Danny Trejo isn’t afraid to face-off against a fearless and formidable female force… At least on camera.

The 68-year-old Mexican American actor is currently in talks to join former-mixed-martial-artist-turned-action-star Gina Carano in the action thriller In the Blood, which is being directed by John Stockwell.

Designed as a starring vehicle for MMA champion Carano and her impressive strength, the film centers on a wife whose husband disappears while they are vacationing in the Caribbean. The grieving wife passionately and recklessly pursues the men she believes kidnapped and killed him.

Trejo, who is set to reprise his role as Machete in the sequel to the cult classic, will play a thug named Big Biz who will face off against Carano.

Principal photography on In the Blood is scheduled to begin November in Puerto Rico.